ARBs have shown excellent efficacy, they have no negative metabolic effects and they cause no accumulation of bradykinin. They also have an ability to activate the angiotensin II type 2 (AT 2) receptors, which causes vasodilatation in the small vessels and presumably leads to additional cardiac and renal protection.
Should a single dose ARB be used in patients with hypertension?
Of course, single dose product is at all times preferred. Several double-blind, head-to-head comparative trials have evaluated the relative antihypertensive efficacy of the ARBs in sufferers with mild to moderate hypertension.
How effective are ARBs for hypertension control?
The 8 available ARBs have variable clinical efficacy when used for control of hypertension. Additive blood pressure (BP) lowering effects have been demonstrated when ARBs are combined with thiazide diuretics or dihydropyridine calcium channel blockers, augmenting hypertension control.
